nichesphere.tl.getColocFilter

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nichesphere.tl.getColocFilter#

nichesphere.tl.getColocFilter(pairCatDF, adj, oneCTints)#

Get filtering object indicating which cell pairs are differentially co-localized

Parameters:

  • pairCatDF (pd.DataFrame) – dataframe of cell pairs and corresponding niche pairs

  • adj (pd.DataFrame) – cell types x cell types adjacency matrix (calculated from the cell cell interaction scores)

  • oneCTints (list) – list of single cell interactions (celltype->celltype)

Returns:

colocFilt – Dataframe with cell type pairs in the form ‘celltype->celltype’ as index and a ‘filter’ column indicating which cell pairs are differentially co-localized with a 1 (or 0 if they are not)

Return type:

pd.DataFrame

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