nichesphere.tl.PIC_BGdoubletsOEratios

nichesphere.tl.PIC_BGdoubletsOEratios#

nichesphere.tl.PIC_BGdoubletsOEratios(adata_singlets, annot_col)#

Generate distribution of O/E ratios for colocalization probabilities of cell type pairs in randomly generated doublets (background dist) for tests in PIC-seq data

Parameters:

  • adata_singlets (AnnData) – anndata object containing singlets (scRNA-seq) data

  • annot_col (str) – name of the cell type annotation column in the anndata object obs

Returns:

OEratios – distribution of O/E ratios for colocalization probabilities of cell type pairs in randomly generated doublets

Return type:

pd.Series